A 3D Human Liver Model of Nonalcoholic Steatohepatitis
Marion Duriez, Agnès Jacquet, Lucile Hoet, Sandrine Roche, Marie‐Dominique Bock, Corinne Rocher, Gilles Haussy, Xavier Vigé, Zsolt Böcskei, Tamara Slavnic, Valérie Martin, Jean‐Claude Guillemot, Michel Didier, Aimo Kannt, Cécile Orsini, Vincent Mikol, A. Fèvre
Abstract
model of NASH disease consisting of four human primary cell-types that exhibits most features of the disease. The 10-day cell viability and cost effectiveness of the model make it suitable for medium throughput drug screening and provide attractive avenues to better understand disease physiology and to identify and characterize new drug targets.
Topics & Concepts
Nonalcoholic steatohepatitisMedicineSteatohepatitisNonalcoholic fatty liver diseaseChronic liver diseaseLiver diseaseInternal medicineGastroenterologyDiseaseFatty liverCirrhosisLiver Disease Diagnosis and TreatmentPancreatic function and diabetesLiver physiology and pathology