A triphenylphosphine coordinated cinnamaldehyde-derived copper(<scp>i</scp>) Fenton-like agent with mitochondrial aggregation damage for chemodynamic therapy
Zhao-Guo Hong, Jingjing Zhong, Sihui Gong, Sudi Huang, Qiongqiong Zhong, Dangdang Ding, He‐Dong Bian, Hong Liang, Fu‐Ping Huang
Abstract
experiments showed that Cin-OD-Cu was capable of effectively inhibiting tumor growth with excellent biocompatibility. We believe this research enriches the limited selection of atomically precise metal complex CDT agents in particular for reactive oxygen species-mediated treatments aimed at inducing mitochondria oxidative damage; we anticipate that it will provide new insights into the development of novel, atomically precise agents for CDT.
Topics & Concepts
CinnamaldehydeCopperTriphenylphosphineChemistryBiochemistryOrganic chemistryCatalysisNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryLanthanide and Transition Metal Complexes