Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR
Nesrine Baatallah, Ahmad Elbahnsi, Jean‐Paul Mornon, B. Chevalier, Iwona Pranke, Nathalie Servel, Renaud Zelli, Jean‐Luc Décout, Aleksander Edelman, Isabelle Sermet‐Gaudelus, Isabelle Callebaut, Alexandre Hinzpeter
Topics & Concepts
Cyclic nucleotide-binding domainAllosteric regulationCystic fibrosis transmembrane conductance regulatorTransmembrane domainProtein foldingMutantDocking (animal)ChemistryBinding siteBinding domainBiologyProtein domainCystic fibrosisComputational biologyCell biologyBiophysicsBiochemistryAmino acidNucleotideGeneGeneticsMedicineNursingEnzymeBacterial Genetics and BiotechnologyCystic Fibrosis Research AdvancesRNA and protein synthesis mechanisms