Colon tissue-accumulating mesoporous carbon nanoparticles loaded with <i>Musca domestica</i> cecropin for ulcerative colitis therapy
Lun Zhang, Shuiqing Gui, Yinghua Xu, Jiali Zeng, Jian Wang, Qingru Chen, Liqian Su, Ziyan Wang, Rui Deng, Fujiang Chu, Wenbin Liu, Xiaobao Jin, Xuemei Lu
Abstract
MDC@MCNs alleviated DSS-induced UC by ameliorating colonic epithelial cells damage, inhibiting inflammation and oxidative stress, enhancing colonic tight junctions, and regulating intestinal flora. This colon-accumulating oral drug delivery nanoplatform may provide a novel and precise therapeutic strategy for UC.
Topics & Concepts
ChemistryIn vivoMolecular biologyPharmacologyBiologyBiotechnologyInflammatory Bowel DiseaseInfant Nutrition and HealthProbiotics and Fermented Foods