Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)
Hao Zhang, Hongyi Zhao, Xiao-Xiao Xi, Yanjie Liu, Minhang Xin, Shuai Mao, Junjie Zhang, Axin Lu, San‐Qi Zhang
Topics & Concepts
Epidermal growth factor receptorProteolysisChemistryChimera (genetics)ProteasomeEpidermal growth factorCell biologyReceptorCancer researchBiochemistryBiologyEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis