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Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Qi Liu, Amita Gupta, Ayse Okesli-Armlovich, Wenjie Qiao, Curt R. Fischer, Mark Smith, Jan E. Carette, Michael C. Bassik, Chaitan Khosla

2020Cell chemical biology35 citationsDOIOpen Access PDF

Topics & Concepts

Dihydroorotate dehydrogenasePyrimidine metabolismRNA polymeraseUridinePolymerasePyrimidineChemistryRNAUracilBiochemistryBiologyEnzymeDNAGenePurineHIV Research and TreatmentMosquito-borne diseases and controlBiochemical and Molecular Research
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