Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial <i>In Vitro</i> and <i>In Vivo</i> Efficacy against Methicillin-Resistant <i>Staphylococcus aureus</i>
Nidja Rehberg, Gereon A. Sommer, Daniel Drießen, Marco Kruppa, Emmanuel T. Adeniyi, Shang Chen, Lin Wang, Karina Wolf, Boris O. A. Tasch, Thomas R. Ioerger, Kui Zhu, Thomas J. J. Müller, Rainer Kalscheuer
Abstract
is independent of pyruvate kinase. Rather, these compounds lead to bacterial membrane permeabilization and cellular efflux of low-molecular-weight molecules.
Topics & Concepts
Staphylococcus aureusChemistryIn vivoEffluxIn vitroNatural productCytotoxicityAntibacterial activityMethicillin-resistant Staphylococcus aureusAntimicrobialMicrobiologyStructure–activity relationshipMinimum inhibitory concentrationBiochemistryBacteriaCombinatorial chemistryBiologyOrganic chemistryBiotechnologyGeneticsCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsAlkaloids: synthesis and pharmacology