Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
Carin C. C. Johansson Seechurn, Matthew O. Kitching, Thomas J. Colacot, Victor Snieckus
Abstract
In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing highly practical methodologies for C-C bond construction. From their original contributions in the early 1970s the landscape of the strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in academia and in industry. In this Review, we attempt to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.
Topics & Concepts
Negishi couplingNobel laureatePerspective (graphical)TRACE (psycholinguistics)History of chemistryChemistryNanotechnologyEpistemologyPhilosophyArtCatalysisLiteratureHistory of scienceMaterials scienceOrganic chemistryVisual artsPoetryLinguisticsCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids