An advanced optical clearing protocol allows label-free detection of tissue necrosis <i>via</i> multiphoton microscopy in injured whole muscle
Dominik Schneidereit, Anita Bröllochs, Paul Ritter, Lucas Kreiß, Zeinab Mokhtari, Andreas Beilhack, Gerhard Krönke, Jochen A. Ackermann, Maria Faas, Anika Grüneboom, Sebastian Schürmann, Oliver Friedrich
Abstract
TDE optical clearing is a versatile tool to study muscle architecture in conjunction with label-free multiphoton imaging in 3D in injury/myopathy models and might also be useful in studying larger biofabricated constructs in regenerative medicine.
Topics & Concepts
MicroscopyNecrosisBiomedical engineeringMedicineMultiphoton fluorescence microscopePathologyChemistryOpticsFluorescence microscopePhysicsFluorescenceAdvanced Fluorescence Microscopy TechniquesPhotoacoustic and Ultrasonic ImagingOptical Coherence Tomography Applications