Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of <i>Candida auris</i>
Ji-Seok Kim, Kyung-Tae Lee, Myung Ha Lee, Eunji Cheong, Yong‐Sun Bahn
Abstract
Despite the recently growing concern of pan-resistant Candida auris infection, the pathogenicity of this ascomycetous fungal pathogen and the signaling circuitries governing its resistance to antifungal drugs are largely unknown. Therefore, we analyzed the pathobiological functions of cyclic AMP (cAMP)/protein kinase A (PKA) signaling pathway in C. auris , which plays conserved roles in the growth and virulence of fungal pathogens.
Topics & Concepts
VirulenceAdenylyl cyclaseBiologyProtein kinase AcAMP-dependent pathwayProtein subunitSignal transductionKinaseCandida aurisAntifungal drugMicrobiologyCell biologyBiochemistryCandida albicansAntifungalGeneAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis