DnaK-Mediated Protein Deamidation: a Potential Mechanism for Virulence and Stress Adaptation in Cronobacter sakazakii
Ping Lu, Juan Xue, Xi Chen, Xuemeng Ji
Abstract
knockout significantly upregulates the abundance of some proteins but also results in the deamidation of many proteins. Our research has identified a connection between molecular chaperones and protein deamidation, which suggests a potential future drug development strategy of targeting DnaK as a drug target.
Topics & Concepts
Cronobacter sakazakiiVirulenceDeamidationBiologyMicrobiologyGeneBacteriaGeneticsBiochemistryEnzymeEnterobacteriaceae and Cronobacter ResearchBacterial Identification and Susceptibility TestingBiosensors and Analytical Detection