Modes of Brain Cell Death Following Intracerebral Hemorrhage
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Abstract
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.
Topics & Concepts
NecroptosisPyroptosisProgrammed cell deathIntracerebral hemorrhageMedicineAutophagyStroke (engine)NeuroscienceApoptosisCause of deathNecrosisPathologyInternal medicineBiologyDiseaseSubarachnoid hemorrhageBiochemistryEngineeringMechanical engineeringIntracerebral and Subarachnoid Hemorrhage ResearchFerroptosis and cancer prognosisInflammasome and immune disorders