Linkage Chemistry of S(VI) Fluorides
Daming Zeng, Wei‐Ping Deng, Xuefeng Jiang
Abstract
Abstract Sulfur(VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction proceeds under metal‐free conditions, and the reactive linkers are variable, enabling access to a diverse class of linkage compounds. Therein, a series of SuFEx linkers emerged has been widely prevalent in diverse fields. The S VI −F bond in comparison to S VI −Cl bond features excellent stability and chemoselectivity. The linkage chemistry primarily involves the formation of S−O and S−N bonds via commercially available phenols and amines, yet less study on C ‐SuFEx linkage. This review will focus on three types of linkage for SuFEx linkers comprising S−O, S−N, and S−C bonds, and we hope to provide a practical guidance for SuFEx linkage chemistry.