Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner
Maria Paola Santini, Daniela Malide, Gabriel E. Hoffman, Gaurav Pandey, Valentina d’Escamard, Aya Nomura-Kitabayashi, Ilsa I. Rovira, Hiroshi Kataoka, Jordi Ochando, Richard P. Harvey, Toren Finkel, Jason C. Kovacic
Abstract
-derived cells persist as terminally differentiated mesenchymal cells. These studies support a context-dependent "yin-yang" biology of tissue-resident mesenchymal progenitor cells, which possess an innate ability to limit injury expansion while also promoting fibrosis in an unfavorable environment.
Topics & Concepts
Progenitor cellMesenchymal stem cellCell biologyBiologyExtracellular matrixFibrosisContext (archaeology)Stromal cellRegeneration (biology)Stem cellCancer researchPathologyMedicinePaleontologyMesenchymal stem cell researchFibroblast Growth Factor ResearchTissue Engineering and Regenerative Medicine