Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa
Guillaume Martinez, Donato Cappetta, Marialucia Telesca, Konrad Urbanek, Giuseppe Castaldo, Magali Dhellemmes, Vincenza Grazia Mele, Teresa Chioccarelli, Veronica Porreca, Anne‐Laure Barbotin, Angèle Boursier, Florian Guillou, Charles Coutton, Sophie Brouillet, Antonella De Angelis, Liberato Berrino, Riccardo Pierantoni, Gilda Cobellis, Rosanna Chianese, Francesco Manfrevola
Abstract
induction of F-actin depolymerization, by cytochalasin D treatment, occurred. Interestingly, F-actin depolymerization was also associated with a correct acrosome repositioning, thus to favor a proper acrosome reaction onset, with changes in sperm nuclear size parameters and histone acetylation rate reaching high-quality conditions. In conclusion, the current work shows a key role of F-actin in the control of IZUMO1 localization as well as chromatin remodeling and acetylation events.