Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment
Andrew E. Massey, Shabnam Malik, Mohammad Sikander, Kyle A. Doxtater, Manish K. Tripathi, Sheema Khan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan, Bilal Bin Hafeez
Abstract
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.
Topics & Concepts
MicrovesiclesDrug deliveryDrugTumor microenvironmentExosomeIsolation (microbiology)MedicineTargeted drug deliveryCancerDiseaseCancer researchBiologyNanotechnologymicroRNABioinformaticsTumor cellsPharmacologyPathologyInternal medicineMaterials scienceBiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery