Continuous Flow Synthesis of Metal–NHC Complexes**
Andreas Simoens, Thomas Scattolin, Thibault Cauwenbergh, Gianmarco Pisanò, Catherine S. J. Cazin, Christian V. Stevens, Steven P. Nolan
Abstract
Abstract The use of weak bases and mild conditions is currently the most sustainable and attractive synthetic approach for the preparation of late‐transition metal complexes, some of which are widely used in catalysis, medicinal chemistry and materials science. Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu I , Au I and Pd II ‐NHC complexes is reported. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. The scalability of the process was exemplified in a multigram‐scale synthesis of [Cu(IPr)Cl].
Topics & Concepts
Flow chemistryContinuous flowAcetoneCatalysisSolventTransition metalChemistryCombinatorial chemistryScalabilityMetalGreen chemistryNanotechnologyOrganic chemistryMaterials scienceComputer scienceBiochemical engineeringReaction mechanismEngineeringDatabaseCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and CatalysisN-Heterocyclic Carbenes in Organic and Inorganic Chemistry