Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α
Hu Chen, Shuhan Yu, Ruidong Ma, Liyuan Deng, Yong Yi, Mengmeng Niu, Chuan Xu, Zhi‐Xiong Jim Xiao
Topics & Concepts
Cancer researchBiologyHistone deacetylase 2Gene knockdownMetastasisEpigeneticsGene silencingTranscription factorEZH2Cancer cellBreast cancerCancerHistoneHistone deacetylaseCell cultureGeneticsGeneEpigenetics and DNA MethylationRNA modifications and cancerUbiquitin and proteasome pathways