Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy
Raúl S. Rangel-Gil, Juan M. Nasrala-Alvarez, Rodolfo J. Romañach, Rafael Méndez
Topics & Concepts
Process analytical technologyMixing (physics)CalibrationNear-infrared spectroscopyRoot mean squareMean squared errorPartial least squares regressionMaterials scienceAnalytical Chemistry (journal)Process (computing)Sampling (signal processing)Process engineeringChemistryMathematicsChromatographyComputer scienceOpticsStatisticsPhysicsWork in processEngineeringElectrical engineeringDetectorQuantum mechanicsOperating systemOperations managementSpectroscopy and Chemometric AnalysesSpectroscopy Techniques in Biomedical and Chemical ResearchAnalytical Chemistry and Chromatography