pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing
Yongping Liang, Meng Li, Yutong Yang, Lipeng Qiao, Huiru Xu, Baolin Guo
Abstract
. In summary, adhesion-enhanced self-healing multifunctional PC/GO/Met hydrogels with stimuli-responsive metformin release ability and easy removability have shown a promoting effect on the healing of chronic athletic diabetic wounds and provide a local-specific drug dual-response release strategy for the treatment of type II diabetic feet.
Topics & Concepts
Wound healingSelf-healing hydrogelsBioadhesiveDiabetic footPharmacologyChemistryMetforminHyaluronic acidAdhesionChitosanControlled releaseAngiogenesisPhenylboronic acidDrug deliveryBiomedical engineeringDiabetes mellitusMedicineSurgeryBiochemistryPolymer chemistryCancer researchEndocrinologyOrganic chemistryAnatomyCatalysisWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementElectrospun Nanofibers in Biomedical Applications