Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic <i>Yersinia</i>
David Balderas, Erin L. Mettert, Hanh N. Lam, Rajdeep Banerjee, Tomas Gverzdys, Pablo Álvarez, Geetha Saarunya, N. Kyle Tanner, Adam Zoubedi, Yahan Wei, Patricia J. Kiley, Victoria Auerbuch
Abstract
encounter during infection, IscR levels increase, leading to modulation of genes involved in iron metabolism, stress resistance, cell envelope remodeling, and subversion of host defenses. These data suggest that IscR senses nutritional immunity to coordinate processes important for bacterial survival within the mammalian host.
Topics & Concepts
VirulenceYersiniaVirulence factorBiologyGeneGenomeGeneticsPathogenic bacteriaComputational biologyMicrobiologyBacteriaYersinia bacterium, plague, ectoparasites researchBacillus and Francisella bacterial researchZoonotic diseases and public health