The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity
Chao Sun, Andreas Nold, Claudia M. Fusco, Vidhya Rangaraju, Tatjana Tchumatchenko, Mike Heilemann, Erin M. Schuman
Abstract
activity. A multifold increase in synaptic nascent protein was evident following both local and global plasticity at respective scales, albeit with substantial heterogeneity between neighboring synapses.
Topics & Concepts
Synaptic plasticityRibosomeSynapseBiologyTranslation (biology)Cell biologyProtein biosynthesisNeuroscienceRNABiochemistryMessenger RNAReceptorGeneNeuroscience and Neuropharmacology ResearchRNA and protein synthesis mechanismsRNA Research and Splicing