Electrochemical Promoted Three-Component Trifluoromethylation/Spirocyclization Reaction of <i>N</i>-Arylsulfonylacrylamides to 4-Azaspiro[4.5]decanes
Zhi-Long Lei, Tai-Chen Liu, Fei‐Hu Cui, Ying‐Ming Pan, Shuhui Li, Haitao Tang
Abstract
An electrochemical facilitated three-component trifluoromethylation/spirocyclization reaction of N -(arylsulfonyl)acrylamides, CF 3 SO 2 Na, and H 2 O has been developed. Without the requirement of chemical oxidants, a number of unexplored trifluoromethylated 4-azaspiro[4.5]decanes were obtained in satisfactory yields under mild conditions. This work provides a new synthetic strategy for fluorine-containing spirocyclic compounds and shows a new perspective for the reactivity study of N -(arylsulfonyl)acrylamides.
Topics & Concepts
TrifluoromethylationChemistryReactivity (psychology)ElectrochemistryComponent (thermodynamics)Combinatorial chemistryFluorinePerspective (graphical)Organic chemistryComputer scienceTrifluoromethylArtificial intelligenceElectrodePathologyAlkylAlternative medicinePhysicsMedicineThermodynamicsPhysical chemistryFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions