A mitochondria-localized iridium(<scp>iii</scp>)–chlorin E6 conjugate for synergistic sonodynamic and two-photon photodynamic therapy against melanoma
Zhuoli Chen, Tao Feng, Jinchao Shen, Johannes Karges, Chengzhi Jin, Yu‐Kun Zhao, Liang‐Nian Ji, Hui Chao
Abstract
A mitochondria-localized iridium( iii )–chlorin e6 conjugate was developed for synergistic sonodynamic and two-photon photodynamic therapy against melanoma A375 cells and A375 mice xenografts.
Topics & Concepts
Sonodynamic therapyPhotodynamic therapyIridiumConjugateChlorinPhotosensitizerMelanomaChemistryPhotochemistryCancer researchMedicineBiochemistryOrganic chemistryMathematicsMathematical analysisCatalysisNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging