Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis
Piera Smeriglio, Fiorella C. Grandi, Spoorthi Davala, Venkata Masarapu, Pier Francesco Indelli, Stuart B. Goodman, Nidhi Bhutani
Abstract
loss. Collectively, these data demonstrate that TET1-mediated 5hmC deposition regulates multiple OA pathways and can be modulated for therapeutic intervention.
Topics & Concepts
OsteoarthritisPathogenesisCancer researchMedicineCell biologyChemistryBiologyPathologyAlternative medicineCancer-related gene regulationEpigenetics and DNA MethylationHIV Research and Treatment