Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors
Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugnière, Maxime Liberelle, Romain Magnez, Xavier Thuru, Marie‐Christine Chartier‐Harlin, Patricia Melnyk, Muriel Gelin, Frédéric Allemand, Jean‐François Guichou, Philippe Cotelle
Topics & Concepts
Hippo signaling pathwayChemistryCell biologyTranscription factorCell growthPDZ domainHEK 293 cellsActivator (genetics)PhosphorylationPlasma protein bindingGeneCancer researchBiologyBiochemistryHippo pathway signaling and YAP/TAZ