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In vivo cross-linking mass spectrometry: Advances and challenges in decoding protein conformational dynamics and complex regulatory networks in living cells

Jing Chen, Qun Zhao, Yukui Zhang, Lihua Zhang, Lihua Zhang

2025Current Opinion in Chemical Biology6 citationsDOI

Topics & Concepts

In vivoChemistryComputational biologyIntramolecular forceMass spectrometryPeptideProtein–protein interactionDecoding methodsCharacterization (materials science)Living cellIntermolecular forceBiophysicsIn vitroNanotechnologyProtein structurePlasma protein bindingLiving systemsInteraction networkBiological systemBiologyIntermolecular interactionDynamics (music)Protein chemistryBiochemistryMolecular dynamicsCell biologyComputer scienceMass Spectrometry Techniques and ApplicationsRNA and protein synthesis mechanisms
In vivo cross-linking mass spectrometry: Advances and challenges in decoding protein conformational dynamics and complex regulatory networks in living cells | Litcius