Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at <i>Cyp1a1</i> upon exposure later in life
Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang, Andrew J. Halayko, Vernon W. Dolinsky, Christopher D. Pascoe, Meaghan J. Jones
2023American Journal of Physiology-Lung Cellular and Molecular Physiology11 citationsDOIOpen Access PDF
Abstract
Here, we isolated effects of prenatal from early postnatal cigarette smoke and showed that exposure to cigarette smoke early in life causes changes in offspring DNA methylation at Cyp1a1 that last through early adulthood but not into late adulthood. We also showed that smoking in adulthood reestablished these DNA methylation patterns at Cyp1a1, suggesting that a mechanism other than DNA methylation results in long-term memory associated with early-life cigarette smoke exposures at this gene.
Topics & Concepts
DNA methylationOffspringSmokeCigarette smokeMethylationPhysiologyBiologyGeneMedicinePregnancyGeneticsToxicologyChemistryGene expressionOrganic chemistryEpigenetics and DNA Methylation