Radiosynthesis and Biological Evaluation of 99mTc Nitrido-Levetiracetam as a Brain Imaging Agent
M. H. Sanad, H. M. Eyssa, F. A. Marzook, Ayman Farag, Syed Faheem Askari Rizvi, Sudip Kumar Mandal, Soumya Stuti Patnaik, A. S. M. Fouzy, Sabry A. Bassem, Francis Verpoort
Abstract
99mTc nitrido-Levetiracetam was prepared using the 99mTc nitrido core for labeling. The reaction conditions were optimized to get the highest radiochemical purity (98%): substrate amount 2 mg, Sn(II) (reducing agent) amount 50 µg, pH 7, 30 min, ambient temperature. The biodistribution studies revealed high brain uptake of 99mTc nitride-Levetiracetam, reaching a maximum of 9% ID/g at 30 min post injection (p.i.). The complex deserves further analysis as a candidate brain imaging agent.
Topics & Concepts
ChemistryLevetiracetamRadiosynthesisBiodistributionReducing agentImaging agentRadiochemistryNuclear chemistryNuclear medicineOrganic chemistryBiochemistryEpilepsyPositron emission tomographyNeuroscienceIn vivoBiotechnologyIn vitroBiologyMedicineRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsBoron Compounds in Chemistry