Cytoplasmic-peroxisomal spatial combination engineering in <i>Candida tropicalis</i> for enhanced terpenoid production
Lihua Zhang, Cheng Fan, Haibing Zhang, Manzhi Zhu, Haiquan Yang, Yuanyuan Xia, Wei Shen, Xianzhong Chen
Abstract
Candida tropicalis was engineered for the de novo biosynthesis of β-carotene, miltiradiene, and α-humulene from glucose. This study offers a green, sustainable, and efficient alternative for terpenoid production.
Topics & Concepts
Candida tropicalisPeroxisomeCytoplasmTerpenoidChemistryCell biologyBiochemistryBiologyYeastReceptorPlant tissue culture and regenerationEnzyme Catalysis and ImmobilizationPlant biochemistry and biosynthesis