Navigating Hemolysis and the Renal Implications of Hemoglobin Toxicity in Cardiac Surgery
Dominik J. Schaer, Christian A. Schaer, Rok Humar, Florence Vallelian, Reney Henderson, Kenichi A. Tanaka, Jerrold H. Levy, Paul W. Buehler
Abstract
Cardiopulmonary bypass–induced hemolysis is linked to acute kidney injury in cardiac surgery. Emerging therapies targeting cell-free hemoglobin (CFHb), like haptoglobin, nitric oxide (NO), and antioxidants, show promise in reducing kidney injury, highlighting the need for further research.
Topics & Concepts
MedicineCardiopulmonary bypassHemolysisHaptoglobinAcute kidney injuryHemoglobinCardiac surgeryNitric oxideKidneyToxicityInternal medicineCardiologyIntensive care medicineAcute Kidney Injury ResearchHemoglobin structure and functionCardiac Arrest and Resuscitation