Design, synthesis, and evaluation of VHL-based EZH2 degraders for breast cancer
Boren Xiao, Zhichao Shi, Jiaqi Liu, Qiuhua Huang, Kaifei Shu, Kaifei Shu, Cailian Zhi, Dandan Zhang, Lihong Wu, Shiqi Yang, Xiliang Zeng, Tingting Fan, Zijian Liu, Yuyang Jiang, Zijian Liu, Yuyang Jiang
Topics & Concepts
EZH2Cancer researchChemistryHistone methyltransferaseApoptosisProteolysisMethyltransferaseAngiogenesisCell cultureCancerBreast cancerHistoneCell growthMethylationBiologyBiochemistryEnzymeGeneticsDNAProtein Degradation and InhibitorsEpigenetics and DNA MethylationCancer-related gene regulation