Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer
Ying Bai, Chao Liang, Jiawei Zhou, Yafeng Liu, Fengxuan Wang, Jian Gao, Jing Wu, Dong Hu
Topics & Concepts
CelastrolChemistryReactive oxygen speciesApoptosisProtein kinase BPharmacologyCancer cellIn vivoCancer researchMAPK/ERK pathwayBiochemistryCancerSignal transductionBiologyMedicineInternal medicineBiotechnologyCell death mechanisms and regulationUbiquitin and proteasome pathwaysATP Synthase and ATPases Research