Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex
Simone Chiola, Kandy L. Napan, Yueqi Wang, Roman M. Lazarenko, Celeste J. Armstrong, Jun Cui, Aleksandr Shcheglovitov
Topics & Concepts
NeuroscienceBiologyDendritic spinePrefrontal cortexNeurotransmissionPostsynaptic potentialExcitatory postsynaptic potentialHippocampusCortex (anatomy)AutismNeocortexAMPA receptorHippocampal formationInhibitory postsynaptic potentialGlutamate receptorPsychologyGeneticsPsychiatryReceptorCognitionCRISPR and Genetic EngineeringAutism Spectrum Disorder ResearchNeuroscience and Neural Engineering