Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Simon W. Rabkin, Chenille N. Wong
Abstract
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+-ATPase, oxidative–nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.
Topics & Concepts
Heart failureEpigeneticsHeart failure with preserved ejection fractionEjection fractionDNA methylationCardiologyMedicineInternal medicineAtrial fibrillationBiologyGeneticsGeneGene expressionCardiovascular Function and Risk FactorsCardiac Structural Anomalies and RepairHeart Failure Treatment and Management