Engineering CAR-T therapies for autoimmune disease and beyond
Emily P. English, Rachel N. Swingler, Simran Patwa, Mehmet Tosun, James F. Howard, Miloš D. Miljković, Christopher M. Jewell
Abstract
Chimeric antigen receptor-T cell (CAR-T) therapy has transformed the management of refractory hematological malignancies. Now that targeting pathogenic cells of interest with antigen-directed cytotoxic T lymphocytes is possible, the field is expanding the reach of CAR-T therapy beyond oncology. Recently, breakthrough progress has been made in the application of CAR-T technology to autoimmune diseases, exploiting the same validated targets that were used by pioneering CAR-T therapies in hematology. Here, we discuss recent advances and outcomes that are paving the way for extension to new therapeutic areas, including autoimmunity.