Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Min‐Ae Song, JY Kim, Matthew W. Gorr, Roy A. Miller, Manjula Karpurapu, Jackie Nguyen, Devki Patel, Kellie J. Archer, Navjotsingh Pabla, Peter G. Shields, Loren E. Wold, John W. Christman, Sangwoon Chung
2023American Journal of Physiology-Lung Cellular and Molecular Physiology20 citationsDOIOpen Access PDF
Abstract
Respiratory immunity is dysregulated in preexisting asthma, and further perturbations by EC use could exacerbate asthma severity. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with preexisting asthma have not been delineated. We found that EC has unique biological impacts in lungs and potential sex differences with loss of TFAM, a key mtDNA regulator, in lung epithelial region from our animal EC study.
Topics & Concepts
AsthmaInflammationTFAMImmunologyMedicineLungRespiratory systemInhalation exposureHouse dust mitePathologyMitochondrionAllergyToxicityInternal medicineBiologyAllergenCell biologyMitochondrial biogenesisAsthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchAir Quality and Health Impacts