ExoDS: a versatile exosome-based drug delivery platform to target cancer cells and cancer stem cells
Swastika Paul, Shrikrishna Bhagat, Lipsa Dash, Himadri Das Mohapatra, Sarita Jena, Suresh K. Verma, Abhishek Dutta
Abstract
. We also observed that ExoDS reduced the expression of cancer stem cell markers in murine tumor tissues. Altogether, this work provides novel insights into how mDC-derived exosomes can be used to specifically target cancer cells and cancer stem cells.
Topics & Concepts
WorkflowCancerCancer stem cellDrug deliveryCancer cellExosomeMode of actionStem cellProcess (computing)DrugCancer researchComputer scienceComputational biologyChemistryMicrovesiclesNanotechnologyCell biologyBiologyMedicinePharmacologyMaterials scienceBiochemistryInternal medicineProgramming languageGenemicroRNADatabaseExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery