Huntington's disease clinical trials update: March 2025
Mena Farag, Sarah J. Tabrizi, Edward J. Wild
Abstract
In this edition of the Huntington's Disease Clinical Trials Update, we expand on the ongoing phase I clinical trial of ALN-HTT02 from Alynlam Pharmaceuticals. We also report on the SAGE-718 (also known as dalzanemdor) program from Sage Therapeutics, with results of the phase II DIMENSION study and the recent termination of the open-label phase III PURVIEW study. Additionally, we discuss recent developments in the regulatory pathway for AMT-130, following discussions between uniQure and the U.S. Food and Drug Administration regarding key aspects of accelerated approval. Finally, we provide a comprehensive listing of all currently registered and ongoing clinical trials in Huntington's disease.
Topics & Concepts
Clinical trialHuntington's diseaseFood and drug administrationNew drug applicationDiseaseMedicineDrug developmentListing (finance)Intensive care medicineDrugInternal medicinePsychiatryPharmacologyEconomicsFinanceGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyAmyotrophic Lateral Sclerosis Research