Treasures old and new: what we can learn regarding the macrocyclic problem from past and present efforts in natural product total synthesis
Maryam Sadat Alehashem, Azhar Ariffin, Paul B. Savage, Wageeh Abdulhadi Yehya Dabdawb, Noel F. Thomas
Abstract
-butyne intramolecular Diels-Alder reaction to install this biaryl moiety. Other unexpected and mechanistically intriguing observations will be described throughout the review.
Topics & Concepts
Intramolecular forceNatural productChemistryCombinatorial chemistryContext (archaeology)MoietyAnnulationTotal synthesisStereochemistryOrganic chemistryCatalysisBiologyPaleontologyOxidative Organic Chemistry ReactionsRadical Photochemical ReactionsSynthetic Organic Chemistry Methods