Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor
Alessandro Bonadio, Bernhard L. Wenig, Alexandra Hockla, Evette S. Radisky, Julia M. Shifman
Topics & Concepts
Matrix metalloproteinaseComputational biologyMutagenesisBiologyProtein engineeringBiochemistryChemistryEnzymeMutationGeneProtease and Inhibitor MechanismsPeptidase Inhibition and AnalysisStudies on Chitinases and Chitosanases