Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body
Niloy Roy, Biswajit Ghosh, Debadrita Roy, Biswajit Bhaumik, Mahendra Nath Roy
Abstract
H NMR and FTIR spectroscopy studies supported the inclusion complexation phenomenon. The results obtained from computational studies were found to be consistent with the experimental data to ascertain the encapsulation of umbelliferone into α-cyclodextrin.
Topics & Concepts
UmbelliferoneChemistryFourier transform infrared spectroscopyCyclodextrinElectrospray ionizationBinding constantFourier transform ion cyclotron resonanceMass spectrometryComputational chemistryAnalytical Chemistry (journal)ChromatographyOrganic chemistryChemical engineeringBinding siteCoumarinEngineeringBiochemistryDrug Solubulity and Delivery SystemsAnalytical Chemistry and ChromatographyAnalytical Methods in Pharmaceuticals