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Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases

Manon Boivin, Jianwen Deng, Véronique Pfister, Erwan Grandgirard, Mustapha Oulad‐Abdelghani, Bastien Morlet, Frank Ruffenach, Luc Négroni, Pascale Koebel, Hugues Jacob, Fabrice Riet, Anke A. Dijkstra, Kathryn McFadden, Clayton A. Wiley, Daojun Hong, Hiroaki Miyahara, Yasushi Iwasaki, Jun Sone, Zhaoxia Wang, Nicolas Charlet‐Berguerand

2021Neuron157 citationsDOIOpen Access PDF

Topics & Concepts

NeurodegenerationTranslation (biology)BiologyOpen reading frameGeneGeneticsCell biologyPathologyNeuroscienceDiseaseMessenger RNAMedicinePeptide sequenceGenetic Neurodegenerative DiseasesGenetics and Neurodevelopmental DisordersRNA Research and Splicing
Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases | Litcius