Three-Component Fusion to Pyrazolo[5,1-<i>a</i>]isoquinolines via Rh-Catalyzed Multiple Order Transformation of Enaminones
Demao Chen, Changfeng Wan, Yunyun Liu, Jie‐Ping Wan
Abstract
]isoquinolines has been realized via the reactions of enaminones, hydrazine hydrochloride, and internal alkynes. By means of Rh catalysis, the extraordinary high-order bond functionalization, including the transformation of aryl C-H, ketone C═O, and alkenyl C-N bonds in the enaminones, marks the major feature of the cascade reactions. The results disclose the individual advantage of enaminones in the design of novel and efficient synthetic methods.
Topics & Concepts
Hydrazine (antidepressant)CatalysisChemistryKetoneCombinatorial chemistryCascade reactionTransformation (genetics)CascadeComponent (thermodynamics)ArylOrganic chemistryBiochemistryAlkylPhysicsChromatographyThermodynamicsGeneCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles