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Design and synthesis of new quinoline-ester/-amide derivatives as potent antiproliferative agent targeting EGFR and BRAFV600E kinases

Aliaa M. Mohassab, Heba A. Hassan, Hesham A. Abou‐Zied, Mikako Fujita, Masami Otsuka, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Mohamed Abdel‐Aziz

2023Journal of Molecular Structure19 citationsDOI

Topics & Concepts

ChemistryQuinolineDocking (animal)MoietyIC50StereochemistryEGFR inhibitorsErlotinibKinaseOximeDoxorubicinLead compoundCombinatorial chemistryIn vitroBiochemistryEpidermal growth factor receptorReceptorOrganic chemistryChemotherapyMedicineSurgeryNursingSynthesis and biological activityLung Cancer Treatments and MutationsMelanoma and MAPK Pathways
Design and synthesis of new quinoline-ester/-amide derivatives as potent antiproliferative agent targeting EGFR and BRAFV600E kinases | Litcius