Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Nanxi Lai, Heming Cheng, Zhisheng Li, Xia Wang, Yeping Ruan, Yingbei Qi, Lin Yang, Fan Fei, Sijie Dai, Liying Chen, Yang Zheng, Cenglin Xu, Jiajia Fang, Shuang Wang, Zhong Chen, Yi Wang
Abstract
activities and histological evidence reveal a disjointed correlation between the two ensembles during FS dynamics. Optogenetic activation of FS-Ens promotes further seizure development, while IP-Ens protects against it. Interestingly, both ensembles are functionally involved in generalized seizures (GS) due to circuit rearrangement. IP-Ens bidirectionally modulates FS but not GS by controlling coherence with hippocampus. This study indicates that the interictal state may represent a seizure-preventing environment, and the interictal-activated ensemble may serve as a potential therapeutic target for epilepsy.