lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1
Yu Hu, Xian Zhang, Hongyan Zai, Wei Jiang, Xiao Liang, Qin Zhu
Abstract
. Mechanistically, DUXAP8 upregulated FOXM1 expression by sponging miR-485-5p and interacting with the RNA-binding protein Fused in Sarcoma (FUS). Functionally, FOXM1 essentially mediated the oncogenic phenotypes of DUXAP8. Collectively, DUXAP8 acts through two distinct mechanisms to upregulate FOXM1 and becomes a pleotropic oncogenic lncRNA in HCC.
Topics & Concepts
BiologyFOXM1Long non-coding RNACancer researchDownregulation and upregulationMetastasisRNAMolecular biologyGeneCancerGeneticsCancer-related molecular mechanisms researchFOXO transcription factor regulationRNA modifications and cancer