One Stone Two Birds: Redox-Sensitive Colocalized Delivery of Cisplatin and Nitric Oxide through Cascade Reactions
Jianbing Wu, Yihui Hu, Hui Ye, Sheng Zhang, Jie Zhu, Duorui Ji, Yihua Zhang, Ya Ding, Zhangjian Huang
Abstract
) and products (cytotoxic cisplatin and tumoricidal NO) for the bio-orthogonal bond-cleavage reaction, which leads to an improved synergistic therapeutic activity for triple-negative breast cancer (TNBC). This new concept of bio-orthogonal dual-prodrug coordinative nanoparticles may inspire further applications in bio-orthogonal chemistry and drug delivery for combination chemotherapy.
Topics & Concepts
ProdrugChemistryCombinatorial chemistryCisplatinNanoparticleCleavage (geology)Nitric oxideCatalysisDrug deliveryNanotechnologyOrganic chemistryMaterials scienceBiochemistryChemotherapyFracture (geology)SurgeryMedicineComposite materialClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and Applications