Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection
Wenkui Dai, Hui Du, Qian Zhou, Sumei Li, Yinan Wang, Jun Hou, Chunlei Guo, Qing Yang, Changzhong Li, Shouxia Xie, Shouxia Xie, Ruifang Wu, Shuai Cheng Li, Ruifang Wu
Abstract
There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.
Topics & Concepts
MetabolomePopulationBiologyHPV infectionVaginal infectionsImmunologyMedicineInternal medicineBioinformaticsMetabolomicsObstetricsCervical cancerCancerEnvironmental healthCervical Cancer and HPV ResearchReproductive tract infections researchGut microbiota and health