Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′<i>H</i>-spiro-pyridine derivatives as a new class of EGFR<sup>Wt</sup>and VEGFR-2 inhibitors with apoptotic inducers
Reham R. Raslan, Yousry A. Ammar, Sawsan A. Fouad, Sadia A. Hessein, Nadia A. M. Shmiess, Ahmed Ragab
Abstract
Design and synthesis a novel of 2-oxo-pyridine and 1′ H -spiro-pyridine derivatives as a new apoptotic inducers agents.
Topics & Concepts
PyridineChemistryIC50ApoptosisMoietyCytotoxicityDoxorubicinStereochemistryCell cultureCell growthMedicinal chemistryIn vitroBiochemistryBiologyChemotherapyGeneticsHedgehog Signaling Pathway StudiesCancer-related Molecular PathwaysAxon Guidance and Neuronal Signaling